6C2Y

Human GRK2 in complex with Gbetagamma subunits and CCG257142

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Beta-adrenergic receptor kinase 1	polymer	689	79676.6	1	UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169)	Homo sapiens (Human)	Beta-ARK-1,G-protein coupled receptor kinase 2
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37416.9	1	UniProt (P62871) Pfam (PF00400)	Bos taurus (Bovine)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	77	8674.0	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (Bovine)	G gamma-I
4	D (A)	(4R,5R,6S)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-N-(2H-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamide	non-polymer		536.5	1	Chemie (EJS)
5	E, F, G (A, B, G)	water	water		18.0	42	Chemie (HOH)

Sequence modifications

A: 1 - 689 (UniProt: P25098)

PDB	External Database	Details
Ala 670	Ser 670	engineered mutation

G: 1 - 71 (UniProt: P63212)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 68	Cys 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	125767.5
Non-Polymers*	Number of molecules	1
	Total formula weight	536.5
All*	Total formula weight	126304.0

*Water molecules are not included.