8INR

Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex

Summary for 8INR

Entry DOI	10.2210/pdb8inr/pdb
EMDB information	35601
Descriptor	HA signal peptide,Melanocortin receptor 5,LgBiT subunit, alpha-melanocyte-stimulating hormone, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywords	human melanocortin receptor 5, g protein-coupled receptor, ligand recpgnition, membrane protein
Biological source	Influenza A virus (A/Victoria/3/1975(H3N2)) More
Total number of polymer chains	5
Total formula weight	148555.05
Authors	Feng, W.B.,Zhou, Q.T.,Chen, X.Y.,Dai, A.T.,Cai, X.Q.,Liu, X.,Zhao, F.H.,Chen, Y.,Ye, C.Y.,Xu, Y.N.,Cong, Z.T.,Li, H.,Lin, S.,Yang, D.H.,Wang, M.W. (deposition date: 2023-03-10, release date: 2023-09-20)
Primary citation	Feng, W.,Zhou, Q.,Chen, X.,Dai, A.,Cai, X.,Liu, X.,Zhao, F.,Chen, Y.,Ye, C.,Xu, Y.,Cong, Z.,Li, H.,Lin, S.,Yang, D.,Wang, M.W. Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discov, 9:81-, 2023 Cited by PubMed: 37524700 DOI: 10.1107/S0907444909042073 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.73 Å)

Structure validation