7VQX

Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs

Summary for 7VQX

Entry DOI	10.2210/pdb7vqx/pdb
EMDB information	32095
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	vasoactive intestinal polypeptide receptor 2, g protein-coupled receptor, ligand recognition, structural protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	6
Total formula weight	180388.44
Authors	Xu, Y.N.,Feng, W.B.,Zhou, Q.T.,Liang, A.Y.,Li, J.,Dai, A.T.,Zhao, F.H.,Yan, J.H.,Chen, C.W.,Li, H.,Zhao, L.H.,Xia, T.,Jiang, Y.,Xu, H.E.,Yang, D.H.,Wang, M.W. (deposition date: 2021-10-21, release date: 2022-05-18)
Primary citation	Xu, Y.,Feng, W.,Zhou, Q.,Liang, A.,Li, J.,Dai, A.,Zhao, F.,Yan, J.,Chen, C.W.,Li, H.,Zhao, L.H.,Xia, T.,Jiang, Y.,Xu, H.E.,Yang, D.,Wang, M.W. A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13:2272-2272, 2022 Cited by PubMed: 35477937 DOI: 10.1038/s41467-022-30041-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation