3PSC

Bovine GRK2 in complex with Gbetagamma subunits

Summary for 3PSC

Related1OMW 3PVU 3PVW 3KRW 3KRX 3CIK
DescriptorBeta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total)
Functional Keywordskinase, serine/threonine-protein kinase, atp-binding, membrane, transferase-signaling protein complex, transferase/signaling protein
Biological sourceBos taurus (bovine)
Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side (Potential) P63212
Total number of polymer chains3
Total molecular weight126402.41
Authors
Thal, D.M.,Tesmer, J.J. (deposition date: 2010-12-01, release date: 2011-06-01, Last modification date: 2011-07-27)
Primary citation
Thal, D.M.,Yeow, R.Y.,Schoenau, C.,Huber, J.,Tesmer, J.J.
Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80:294-303, 2011
PubMed: 21596927 (PDB entries with the same primary citation)
DOI: 10.1124/mol.111.071522
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.67 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24660.3%3.3%7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution