7PWD
Structure of an inhibited GRK2-G-beta and G-gamma complex
Summary for 7PWD
Entry DOI | 10.2210/pdb7pwd/pdb |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total) |
Functional Keywords | proteros, grk2, inhibition, heart failure, kinase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 127493.09 |
Authors | Faucher, N.,Tauchert, M.J.,Konz Makino, D.L.,Vuillard, L.M. (deposition date: 2021-10-06, release date: 2021-10-20, Last modification date: 2024-06-19) |
Primary citation | Balo, T.,Sapi, A.,Kiss, A.,Raimbaud, E.,Paysant, J.,Cattin, M.E.,Berger, S.,Kotschy, A.,Faucher, N. Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022 Cited by DOI: 10.1007/s00706-021-02889-2PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report