7PWD
Structure of an inhibited GRK2-G-beta and G-gamma complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-adrenergic receptor kinase 1 | polymer | 697 | 80649.7 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB | Homo sapiens (Human) | Beta-ARK-1,G-protein coupled receptor kinase 2 |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62871) Pfam (PF00400) In PDB | Bos taurus (Bovine) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 77 | 8674.0 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
4 | A | 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide | non-polymer | 351.3 | 1 | Chemie (8DS) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
6 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
7 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
8 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 1 - 689 (UniProt: P25098)
G: 1 - 71 (UniProt: P63212)
PDB | External Database | Details |
---|---|---|
Ala 670 | Ser 670 | engineered mutation |
Gly 690 | - | expression tag |
Ser 691 | - | expression tag |
His 692 | - | expression tag |
His 693 | - | expression tag |
His 694 | - | expression tag |
His 695 | - | expression tag |
His 696 | - | expression tag |
His 697 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 126740.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 752.5 | |
All* | Total formula weight | 127493.1 |