8HIK
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7WJ5
| Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity | 分子名称: | Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T. | 登録日 | 2022-01-05 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. Elife, 11, 2022
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6D32
| Crystal structure of Xenopus Smoothened in complex with cyclopamine | 分子名称: | Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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7W0O
| Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8XV9
| Fedratinib-bound human SLC19A3 | 分子名称: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Soluble cytochrome b562,Thiamine transporter 2 | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | 登録日 | 2024-01-14 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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7TX7
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7EZC
| Adenosine A2a receptor mutant-I92N | 分子名称: | 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,Soluble cytochrome b562 | 著者 | Cui, M, Zhou, Q, Yao, D, Zhao, S, Song, G. | 登録日 | 2021-06-01 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of a constitutive active mutant of adenosine A 2A receptor. Iucrj, 9, 2022
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6USF
| CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-26 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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7BW0
| Active human TGR5 complex with a synthetic agonist 23H | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. | 登録日 | 2020-04-12 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
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6D35
| Crystal structure of Xenopus Smoothened in complex with cholesterol | 分子名称: | CHOLESTEROL, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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8F7C
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8DRA
| LRRC8A:C conformation 2 (oblong) LRR mask | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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5NJ6
| Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in ternary complex with Fab3949 and AZ7188 at 4.0 angstrom resolution | 分子名称: | Fab3949 H, Fab3949 L, Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2 | 著者 | Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N. | 登録日 | 2017-03-28 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structural insight into allosteric modulation of protease-activated receptor 2. Nature, 545, 2017
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8DRO
| LRRC8A:C conformation 1 (round) LRR focus 2 | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-21 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DRN
| LRRC8A:C conformation 1 (round) LRR focus 1 | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-21 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7E
| LRRC8A(T48D):C conformation 2 top focus | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-11-18 | 公開日 | 2023-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DRQ
| LRRC8A:C conformation 1 (round) LRR focus 3 | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-07-21 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7D
| LRRC8A(T48D):C conformation 2 top focus | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-11-18 | 公開日 | 2023-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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6MH8
| High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct | 著者 | Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W. | 登録日 | 2018-09-17 | 公開日 | 2019-04-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. Iucrj, 6, 2019
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7W0N
| Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8F7J
| LRRC8A(T48D):C conformation 2 top focus | 分子名称: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | 著者 | Kern, D.M, Brohawn, S.G. | 登録日 | 2022-11-18 | 公開日 | 2023-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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6CMO
| Rhodopsin-Gi complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | 著者 | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | 登録日 | 2018-03-05 | 公開日 | 2018-06-20 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
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1APC
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1QPU
| SOLUTION STRUCTURE OF OXIDIZED ESCHERICHIA COLI CYTOCHROME B562 | 分子名称: | CYTOCHROME B562, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Arnesano, F, Banci, L, Bertini, I, Faraone-Mennella, J, Rosato, A, Barker, P.D, Fersht, A.R. | 登録日 | 1999-05-30 | 公開日 | 1999-06-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of oxidized Escherichia coli cytochrome b562. Biochemistry, 38, 1999
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1QQ3
| THE SOLUTION STRUCTURE OF THE HEME BINDING VARIANT ARG98CYS OF OXIDIZED ESCHERICHIA COLI CYTOCHROME B562 | 分子名称: | CYTOCHROME B562, HEME B/C | 著者 | Arnesano, F, Banci, L, Bertini, I, Ciofi-Baffoni, S, Barker, P.D, Woodyear, T. | 登録日 | 1999-06-10 | 公開日 | 2000-05-24 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural consequences of b- to c-type heme conversion in oxidized Escherichia coli cytochrome b562. Biochemistry, 39, 2000
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