8DRO

LRRC8A:C conformation 1 (round) LRR focus 2

Summary for 8DRO

Entry DOI	10.2210/pdb8dro/pdb
Related	8DR8 8DRA 8DRE 8DRK 8DRN
EMDB information	27674 27675 27676 27677 27678 27679
Descriptor	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 (1 entity in total)
Functional Keywords	ion channel, volume-regulation, membrane protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	211060.20
Authors	Kern, D.M.,Brohawn, S.G. (deposition date: 2022-07-21, release date: 2023-03-08, Last modification date: 2024-06-12)
Primary citation	Kern, D.M.,Bleier, J.,Mukherjee, S.,Hill, J.M.,Kossiakoff, A.A.,Isacoff, E.Y.,Brohawn, S.G. Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30:841-852, 2023 Cited by PubMed: 36928458 DOI: 10.1038/s41594-023-00944-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.06 Å)

Structure validation