Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DRO

LRRC8A:C conformation 1 (round) LRR focus 2

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005506	molecular_function	iron ion binding
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space
B	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022900	biological_process	electron transport chain
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	44
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	48
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	44
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	44
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	46
Details	Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	46
Details	Repeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	44
Details	Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	44
Details	Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	44
Details	Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	42
Details	Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	44
Details	Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	46
Details	Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Motif: {"description":"Di-leucine motif","evidences":[{"source":"UniProtKB","id":"Q8IWT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)