8F7E

LRRC8A(T48D):C conformation 2 top focus

Summary for 8F7E

Entry DOI	10.2210/pdb8f7e/pdb
Related	8F74 8F75 8F77 8F79 8F7B 8F7D 8F7J
EMDB information	28894 28895 28897 28898 28901 28903 28904 28905
Descriptor	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 (1 entity in total)
Functional Keywords	ion channel, volume-regulation, membrane protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	211088.17
Authors	Kern, D.M.,Brohawn, S.G. (deposition date: 2022-11-18, release date: 2023-03-08, Last modification date: 2024-05-22)
Primary citation	Kern, D.M.,Bleier, J.,Mukherjee, S.,Hill, J.M.,Kossiakoff, A.A.,Isacoff, E.Y.,Brohawn, S.G. Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30:841-852, 2023 Cited by PubMed: 36928458 DOI: 10.1038/s41594-023-00944-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.13 Å)

Structure validation