8F7E
LRRC8A(T48D):C conformation 2 top focus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022900 | biological_process | electron transport chain |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1220 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:29769723 |
| Chain | Residue | Details |
| B | MET-91-PRO-70 | |
| B | TRP143-TYR264 | |
| B | TRP342-ALA810 | |
| C | MET-91-PRO-70 | |
| C | TRP143-TYR264 | |
| C | TRP342-ALA810 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 174 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:30775971, ECO:0007744|PDB:6NZW, ECO:0007744|PDB:6NZZ, ECO:0007744|PDB:6O00 |
| Chain | Residue | Details |
| B | TRP-69-VAL-45 | |
| B | TYR124-PHE142 | |
| B | MET265-VAL286 | |
| B | LEU317-TRP341 | |
| C | TRP-69-VAL-45 | |
| C | TYR124-PHE142 | |
| C | MET265-VAL286 | |
| C | LEU317-TRP341 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 58 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:29769723 |
| Chain | Residue | Details |
| B | HIS287-THR316 | |
| C | HIS287-THR316 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Required for anion selectivity => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| B | ARG103 | |
| C | ARG103 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| B | MET-91 | |
| C | MET-91 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| B | THR200 | |
| C | THR200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| B | SER202 | |
| C | SER202 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| B | THR215 | |
| C | THR215 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8IWT6 |
| Chain | Residue | Details |
| B | SER217 | |
| C | SER217 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN-26 | |
| C | ASN-26 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| B | TRP-9 | |
| B | ILE86 | |
| C | TRP-9 | |
| C | ILE86 |
