8SHF
 
 | | CCT-G beta 5 complex closed state 7 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | Authors: | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | Deposit date: | 2023-04-14 | | Release date: | 2023-11-01 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8SHT
 | | CCT G beta 5 complex closed state 14 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | Authors: | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | Deposit date: | 2023-04-14 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8SHN
 | | CCT-G beta 5 complex closed state 6 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | Authors: | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | Deposit date: | 2023-04-14 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8SHQ
 | | CCT G beta 5 complex closed state 12 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | Authors: | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | Deposit date: | 2023-04-14 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8SHG
 | | CCT G beta 5 complex closed state 9 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | Authors: | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | Deposit date: | 2023-04-14 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8T3Q
 | | Cryo-EM structure of the DHA bound FFA4-Gq complex | | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | | Deposit date: | 2023-06-07 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
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8T3O
 | | Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | | Descriptor: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ... | | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | | Deposit date: | 2023-06-07 | | Release date: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
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8T3S
 | | Cryo-EM structure of the Butyrate bound FFA2-Gq complex | | Descriptor: | CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | | Deposit date: | 2023-06-07 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
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8SZI
 | | Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
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8SZG
 | | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
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8SZH
 | | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
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8SMV
 | | GPR161 Gs heterotrimer | | Descriptor: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hoppe, N, Manglik, A, Harrison, S. | | Deposit date: | 2023-04-26 | | Release date: | 2024-02-21 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Nat.Struct.Mol.Biol., 31, 2024
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8SL3
 | | Human adenylyl Cyclase 5 in complex with Gbg | | Descriptor: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yen, Y.C, Tesmer, J.J.G. | | Deposit date: | 2023-04-20 | | Release date: | 2024-04-03 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia.
Nat.Struct.Mol.Biol., 31, 2024
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8TAS
 | | PRC2 monomer bound to nucleosome | | Descriptor: | DNA (226-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-27 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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8T9G
 | | Automethylated PRC2 dimer bound to nucleosome | | Descriptor: | DNA (226-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-23 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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8TB9
 | | PRC2-J119-450 monomer bound to H1-nucleosome | | Descriptor: | DNA (226-MER), Histone H1.0, Histone H2A type 1, ... | | Authors: | Sauer, P.V, Cookis, T, Pavlenko, E, Nogales, E, Poepsel, S. | | Deposit date: | 2023-06-28 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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8THL
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8THK
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8TID
 | | Combined linker domain of N-DRC and associated proteins Tetrahymena | | Descriptor: | AAA family ATPase CDC48 subfamily protein, CFAP20, Calmodulin 7-2, ... | | Authors: | Ghanaeian, A.G, Majhi, S.M, McCaffrey, C.M, Nami, B.N, Black, C.B, Yang, S.K, Legal, T.L, Papoulas, O.P, Janowska, M.J, Valente-Paterno, M.V, Marcotte, E.M, Wloga, D.W, Bui, K.H. | | Deposit date: | 2023-07-19 | | Release date: | 2023-09-27 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism.
Nat Commun, 14, 2023
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8TO0
 | | 48-nm repeating structure of doublets from mouse sperm flagella | | Descriptor: | Cilia- and flagella- associated protein 210, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | | Authors: | Chen, Z, Shiozak, M, Hass, K.M, Skinner, W, Zhao, S, Guo, C, Polacco, B.J, Yu, Z, Krogan, N.J, Kaake, R.M, Vale, R.D, Agard, D.A. | | Deposit date: | 2023-08-02 | | Release date: | 2023-11-01 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
Cell, 186, 2023
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8U26
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8U1U
 | | Structure of a class A GPCR/agonist complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sun, D, Johnson, M, Masureel, M. | | Deposit date: | 2023-09-02 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
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8U8F
 | | GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs. | | Descriptor: | G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Russell, I.C, Belousoff, M.J, Sexton, P. | | Deposit date: | 2023-09-17 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3.
Biochemistry, 63, 2024
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8U4N
 | | Structure of Apo CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 2024
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8U4P
 | | Structure of AMD3100-bound CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 2024
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