8U8F

GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs.

Summary for 8U8F

Entry DOI	10.2210/pdb8u8f/pdb
EMDB information	42023
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	gpr3, orphan gpcr, gpcr, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	131533.92
Authors	Russell, I.C.,Belousoff, M.J.,Sexton, P. (deposition date: 2023-09-17, release date: 2024-03-06, Last modification date: 2024-03-13)
Primary citation	Russell, I.C.,Zhang, X.,Bumbak, F.,McNeill, S.M.,Josephs, T.M.,Leeming, M.G.,Christopoulos, G.,Venugopal, H.,Flocco, M.M.,Sexton, P.M.,Wootten, D.,Belousoff, M.J. Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry, 63:625-631, 2024 Cited by PubMed: 38376112 DOI: 10.1021/acs.biochem.3c00647 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.49 Å)

Structure validation