4O4I
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![BU of 4o4i by Molmil](/molmil-images/mine/4o4i) | Tubulin-Laulimalide-Epothilone A complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, EPOTHILONE A, ... | Authors: | Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O. | Deposit date: | 2013-12-18 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53, 2014
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6FKJ
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![BU of 6fkj by Molmil](/molmil-images/mine/6fkj) | Tubulin-TUB075 complex | Descriptor: | (5~{S})-2-[(~{E})-~{N}-(2-ethoxyphenyl)-~{C}-methyl-carbonimidoyl]-3-oxidanyl-5-phenyl-cyclohex-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E, Steinmetz, M.O, Priego, E.-M. | Deposit date: | 2018-01-24 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.148 Å) | Cite: | High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. Sci Rep, 8, 2018
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6FKL
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![BU of 6fkl by Molmil](/molmil-images/mine/6fkl) | Tubulin-TUB015 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{1-[(2-Methoxyphenyl)amino]ethylidene}-5-phenyl-1,3-cyclohexanedione, CALCIUM ION, ... | Authors: | Prota, A.E, Steinmetz, M.O, Priego, E.-M. | Deposit date: | 2018-01-24 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. Sci Rep, 8, 2018
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5LA6
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![BU of 5la6 by Molmil](/molmil-images/mine/5la6) | Tubulin-pironetin complex | Descriptor: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Prota, A.E, Setter, J, Waight, A.B, Bargsten, K, Murga, J, Diaz, J.F, Steinmetz, M.O. | Deposit date: | 2016-06-13 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. J.Mol.Biol., 428, 2016
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5LXS
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![BU of 5lxs by Molmil](/molmil-images/mine/5lxs) | Tubulin-KS-1-199-32 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Prota, A.E, Steinmetz, M.O. | Deposit date: | 2016-09-22 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of Microtubule Stabilization by Discodermolide. Chembiochem, 18, 2017
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5LOV
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![BU of 5lov by Molmil](/molmil-images/mine/5lov) | DZ-2384 tubulin complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DZ 2384, ... | Authors: | Prota, A.E, Steinmetz, M.O, Shore, G.C, Brouhard, G, Roulston, A. | Deposit date: | 2016-08-10 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med, 8, 2016
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5LXT
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![BU of 5lxt by Molmil](/molmil-images/mine/5lxt) | Tubulin-Discodermolide complex | Descriptor: | (+)-Discodermolide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E, Steinmetz, M.O. | Deposit date: | 2016-09-22 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis of Microtubule Stabilization by Discodermolide. Chembiochem, 18, 2017
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8R67
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![BU of 8r67 by Molmil](/molmil-images/mine/8r67) | tubulin-cryptophycin complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(3~{S},10~{R},13~{E},16~{S})-10-[(3-chloranyl-4-methoxy-phenyl)methyl]-6,6-dimethyl-2,5,9,12-tetrakis(oxidanylidene)-16-[(1~{S})-1-[(2~{R},3~{R})-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-en-3-yl]ethanoic acid, CALCIUM ION, ... | Authors: | Abel, A.C, Muehlethaler, T, Dessin, C, Steinmetz, M.O, Sewald, N, Prota, A.E. | Deposit date: | 2023-11-21 | Release date: | 2024-05-22 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Bridging the maytansine and vinca sites: Cryptophycins target beta-tubulin's T5-loop. J.Biol.Chem., 300, 2024
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8RIV
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![BU of 8riv by Molmil](/molmil-images/mine/8riv) | T2R-TTL-1-K08 complex | Descriptor: | (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P. | Deposit date: | 2023-12-19 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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6HX8
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![BU of 6hx8 by Molmil](/molmil-images/mine/6hx8) | Tubulin-STX3451 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Dohle, W, Prota, A.E, Menchon, G, Hamel, E, Steinmetz, M.O, Potter, B.V.L. | Deposit date: | 2018-10-16 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure. ACS Omega, 4, 2019
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1KKE
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![BU of 1kke by Molmil](/molmil-images/mine/1kke) | |
1XQP
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![BU of 1xqp by Molmil](/molmil-images/mine/1xqp) | Crystal structure of 8-oxoguanosine complexed Pa-AGOG, 8-oxoguanine DNA glycosylase from Pyrobaculum aerophilum | Descriptor: | 2'-DEOXY-8-OXOGUANOSINE, 8-oxoguanine DNA glycosylase | Authors: | Lingaraju, G.M, Sartori, A.A, Kostrewa, D, Prota, A.E, Jiricny, J, Winkler, F.K. | Deposit date: | 2004-10-13 | Release date: | 2004-11-16 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure Structure, 13, 2005
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1XQO
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![BU of 1xqo by Molmil](/molmil-images/mine/1xqo) | Crystal structure of native Pa-AGOG, 8-oxoguanine DNA glycosylase from Pyrobaculum aerophilum | Descriptor: | 8-oxoguanine DNA glycosylase | Authors: | Lingaraju, G.M, Sartori, A.A, Kostrewa, D, Prota, A.E, Jiricny, J, Winkler, F.K. | Deposit date: | 2004-10-13 | Release date: | 2004-11-16 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure Structure, 13, 2005
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2X1X
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![BU of 2x1x by Molmil](/molmil-images/mine/2x1x) | CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, ... | Authors: | Leppanen, V.-M, Prota, A.E, Jeltsch, M, Anisimov, A, Kalkkinen, N, Strandin, T, Lankinen, H, Goldman, A, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2010-01-08 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2. Proc.Natl.Acad.Sci.USA, 107, 2010
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2X1W
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![BU of 2x1w by Molmil](/molmil-images/mine/2x1w) | Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CESIUM ION, ... | Authors: | Leppanen, V.M, Prota, A.E, Jeltsch, M, Anisimov, A, Kalkkinen, N, Strandin, T, Lankinen, H, Goldman, A, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2010-01-08 | Release date: | 2010-03-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2. Proc.Natl.Acad.Sci.USA, 107, 2010
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7AU5
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![BU of 7au5 by Molmil](/molmil-images/mine/7au5) | Tubulin-noscapine-analogue-14e complex | Descriptor: | (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Yong, C, Devine, S.M, Abel, A.-C, Muthiah, D, Gao, X, Callaghan, R, Capuano, B, Steinmetz, M.O, Prota, A.E, Scammels, P.J. | Deposit date: | 2020-11-02 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. Chemmedchem, 16, 2021
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8B7A
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![BU of 8b7a by Molmil](/molmil-images/mine/8b7a) | Tubulin - maytansinoid - 4 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Boiarska, Z, Perez-Pena, H, Abel, A.-C, Marzullo, P, Alvarez-Bernad, B, Bonato, F, Santini, B, Horvath, D, Lucena-Agell, D, Vasile, F, Sironi, M, Diaz, F.J, Steinmetz, M.O, Prota, A.E, Piaraccini, S, Passarella, D. | Deposit date: | 2022-09-29 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics. Chemistry, 29, 2023
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8B7C
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![BU of 8b7c by Molmil](/molmil-images/mine/8b7c) | Tubulin-maytansinoid-12 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Boiarska, Z, Perez-Pena, H, Abel, A.-C, Marzullo, P, Alvarez-Bernad, B, Bonato, F, Santini, B, Horvath, D, Lucena-Agell, D, Vasile, F, Sironi, M, Diaz, J.F, Steinmetz, M.O, Prota, A.E, Pieraccini, S, Passarella, D. | Deposit date: | 2022-09-29 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics. Chemistry, 29, 2023
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8B7B
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![BU of 8b7b by Molmil](/molmil-images/mine/8b7b) | Tubulin - maytansinoid - 6 complex | Descriptor: | (~{Z})-11-[[(1~{R},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy]-11-oxidanylidene-undec-2-enoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Boiarska, Z, Perez-Pena, H, Abel, A.-C, Marzullo, P, Alvarez-Bernad, B, Bonato, F, Santini, B, Horvath, D, Lucena-Agell, D, Vasile, F, Sironi, M, Diaz, J.F, Steinmetz, M.O, Prota, A.E, Pieraccini, S, Passarella, D. | Deposit date: | 2022-09-29 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics. Chemistry, 29, 2023
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6QTN
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![BU of 6qtn by Molmil](/molmil-images/mine/6qtn) | Tubulin-cyclostreptin complex | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Balaguer, F.d.A, Muehlethaler, T, Estevez-Gallego, J, Calvo, E, Gimenez-Abian, J.F, Risinger, A.L, Sorensen, E.J, Vanderwal, C.D, Altmann, K.-H, Mooberry, S.L, Steinmetz, M.O, Oliva, M.A, Prota, A.E, Diaz, J.F. | Deposit date: | 2019-02-25 | Release date: | 2019-04-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands. Int J Mol Sci, 20, 2019
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6Y6D
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![BU of 6y6d by Molmil](/molmil-images/mine/6y6d) | Tubulin-7-Aminonoscapine complex | Descriptor: | (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Oliva, M.A, Prota, A.E, Rodriguez-Salarichs, J, Gu, W, Bennani, Y.L, Jimenez-Barbero, J, Canales, A, Steinmetz, M.O, Diaz, J.F. | Deposit date: | 2020-02-26 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of Noscapine Activation for Tubulin Binding. J.Med.Chem., 63, 2020
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6SES
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![BU of 6ses by Molmil](/molmil-images/mine/6ses) | Tubulin-B2 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Guo, B, Rodriguez-Gabin, A, Prota, A.E, Muehlethaler, T, Zhang, N, Ye, K, Steinmetz, M.O, Band Horwitz, S, Smith III, A.B, McDaid, H.M. | Deposit date: | 2019-07-30 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence. Mol.Pharmacol., 98, 2020
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6S9E
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![BU of 6s9e by Molmil](/molmil-images/mine/6s9e) | Tubulin-GDP.AlF complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALUMINUM FLUORIDE, CALCIUM ION, ... | Authors: | Oliva, M.A, Estevez-Gallego, J, Diaz, J.F, Prota, A.E, Steinmetz, M.O, Balaguer, F.A, Lucena-Agell, D. | Deposit date: | 2019-07-12 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural model for differential cap maturation at growing microtubule ends. Elife, 9, 2020
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6QQN
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![BU of 6qqn by Molmil](/molmil-images/mine/6qqn) | Tubulin-TH588 complex | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Patterson, J.C, Joughin, B.A, Prota, A.E, Muehlethaler, T, Jonas, O.H, Whitman, M.A, Varmeh, S, Chen, S, Balk, S.P, Steinmetz, M.O, Lauffenburger, D.A, Yaffe, M.B. | Deposit date: | 2019-02-18 | Release date: | 2019-07-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Syst, 9, 2019
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7Z7D
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![BU of 7z7d by Molmil](/molmil-images/mine/7z7d) | Tubulin-Todalam-Vinblastine-complex | Descriptor: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-03-15 | Release date: | 2022-04-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61, 2022
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