2X1W

Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2

Summary for 2X1W

• Entry DOI: 10.2210/pdb2x1w/pdb
• Related: 1VR2 1Y6A 1Y6B 1YWN 2X1X
• Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR C, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: hormone-signaling protein complex, angiogenesis, glycoprotein, host-virus interaction, membrane, receptor, lymphangiogenesis, immunoglobulin domain, developmental protein, transmembrane, phosphoprotein, disulfide bond, mitogen, hormone/signaling protein
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 8
• Total formula weight: 153988.60

Authors

Leppanen, V.M.,Prota, A.E.,Jeltsch, M.,Anisimov, A.,Kalkkinen, N.,Strandin, T.,Lankinen, H.,Goldman, A.,Ballmer-Hofer, K.,Alitalo, K. (deposition date: 2010-01-08, release date: 2010-03-09, Last modification date: 2020-07-29)

• Primary citation: Leppanen, V.M.,Prota, A.E.,Jeltsch, M.,Anisimov, A.,Kalkkinen, N.,Strandin, T.,Lankinen, H.,Goldman, A.,Ballmer-Hofer, K.,Alitalo, K.; Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2.; Proc.Natl.Acad.Sci.USA, 107:2425-, 2010; PubMed: 20145116; DOI: 10.1073/PNAS.0914318107

Experimental method

X-RAY DIFFRACTION (2.7 Å)