2X1W

Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	VASCULAR ENDOTHELIAL GROWTH FACTOR C	polymer	110	12390.2	4	UniProt (P49767) Pfam (PF00341)	HOMO SAPIENS (HUMAN)	VEGF-C, VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN, VRP, FLT4 LIGAND, FLT4-L
2	E, F, G, H (L, M, N, O)	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	polymer	213	23909.3	4	UniProt (P35968) Pfam (PF21339) Pfam (PF00047)	HOMO SAPIENS (HUMAN)	VEGF RECEPTOR 2, VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, CD309, FLK-1
3	I, J, K, L, M... (E, F, G, H, I...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	9	In PDB GlyTouCan (G15407YE)
4	Q, R, T, U (Q, R, T, U)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	V, W (B, C)	CESIUM ION	non-polymer		132.9	2	Chemie (CS)
6	AA, BA, CA, DA, X... (N, O, L)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
7	EA, FA, GA, HA, IA... (A, B, C, D, L...)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, B, C, D: 112 - 215 (UniProt: P49767)

PDB	External Database	Details
Ala 137	Cys 137	engineered mutation

A, B, C, D: 216 - 221 (PDB: 2X1W)
L, M, N, O: 120 - 326 (UniProt: P35968)
L, M, N, O: 327 - 332 (PDB: 2X1W)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	145197.9
Branched	Number of molecules	13
	Total formula weight	6976.5
Non-Polymers*	Number of molecules	9
	Total formula weight	1814.3
All*	Total formula weight	153988.6

*Water molecules are not included.