2X1W
Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | VASCULAR ENDOTHELIAL GROWTH FACTOR C | polymer | 110 | 12390.2 | 4 | UniProt (P49767) Pfam (PF00341) In PDB | HOMO SAPIENS (HUMAN) | VEGF-C, VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN, VRP, FLT4 LIGAND, FLT4-L |
2 | L, M, N, O | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | polymer | 213 | 23909.3 | 4 | UniProt (P35968) Pfam (PF21339) Pfam (PF00047) In PDB | HOMO SAPIENS (HUMAN) | VEGF RECEPTOR 2, VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, CD309, FLK-1 |
3 | E, F, G, H, I... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 9 | In PDB GlyTouCan (G15407YE) | |||
4 | Q, R, T, U | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
5 | B, C | CESIUM ION | non-polymer | 132.9 | 2 | Chemie (CS) | |||
6 | N, O, L | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
7 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 112 - 215 (UniProt: P49767)
A, B, C, D: 216 - 221 (PDB: 2X1W)
L, M, N, O: 120 - 326 (UniProt: P35968)
L, M, N, O: 327 - 332 (PDB: 2X1W)
PDB | External Database | Details |
---|---|---|
Ala 137 | Cys 137 | engineered mutation |
L, M, N, O: 120 - 326 (UniProt: P35968)
L, M, N, O: 327 - 332 (PDB: 2X1W)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 145197.9 | |
Branched | Number of molecules | 13 |
Total formula weight | 6976.5 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1814.3 | |
All* | Total formula weight | 153988.6 |