8B7C

Tubulin-maytansinoid-12 complex

Summary for 8B7C

Entry DOI	10.2210/pdb8b7c/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, [(1~{S},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl] 4-[2-(2-azanylhydrazinyl)ethyl]benzoate, ... (13 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	265353.68
Authors	Boiarska, Z.,Perez-Pena, H.,Abel, A.-C.,Marzullo, P.,Alvarez-Bernad, B.,Bonato, F.,Santini, B.,Horvath, D.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Diaz, J.F.,Steinmetz, M.O.,Prota, A.E.,Pieraccini, S.,Passarella, D. (deposition date: 2022-09-29, release date: 2023-08-23)
Primary citation	Boiarska, Z.,Perez-Pena, H.,Abel, A.C.,Marzullo, P.,Alvarez-Bernad, B.,Bonato, F.,Santini, B.,Horvath, D.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Diaz, J.F.,Prota, A.E.,Pieraccini, S.,Passarella, D. Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics. Chemistry, 29:e202203431-e202203431, 2023 Cited by PubMed: 36468686 DOI: 10.1002/chem.202203431 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation