6QTN

Tubulin-cyclostreptin complex

Summary for 6QTN

Entry DOI	10.2210/pdb6qtn/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cyclostreptin, ... (14 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	265671.68
Authors	Balaguer, F.d.A.,Muehlethaler, T.,Estevez-Gallego, J.,Calvo, E.,Gimenez-Abian, J.F.,Risinger, A.L.,Sorensen, E.J.,Vanderwal, C.D.,Altmann, K.-H.,Mooberry, S.L.,Steinmetz, M.O.,Oliva, M.A.,Prota, A.E.,Diaz, J.F. (deposition date: 2019-02-25, release date: 2019-04-03, Last modification date: 2024-01-24)
Primary citation	Balaguer, F.A.,Muhlethaler, T.,Estevez-Gallego, J.,Calvo, E.,Gimenez-Abian, J.F.,Risinger, A.L.,Sorensen, E.J.,Vanderwal, C.D.,Altmann, K.H.,Mooberry, S.L.,Steinmetz, M.O.,Oliva, M.A.,Prota, A.E.,Diaz, J.F. Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands. Int J Mol Sci, 20:-, 2019 Cited by PubMed: 30897704 DOI: 10.3390/ijms20061392 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation