8R67

tubulin-cryptophycin complex

Summary for 8R67

Entry DOI	10.2210/pdb8r67/pdb
Descriptor	Detyrosinated tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ... (14 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	266326.15
Authors	Abel, A.C.,Muehlethaler, T.,Dessin, C.,Steinmetz, M.O.,Sewald, N.,Prota, A.E. (deposition date: 2023-11-21, release date: 2024-05-22, Last modification date: 2024-06-12)
Primary citation	Abel, A.C.,Muhlethaler, T.,Dessin, C.,Schachtsiek, T.,Sammet, B.,Sharpe, T.,Steinmetz, M.O.,Sewald, N.,Prota, A.E. Bridging the maytansine and vinca sites: Cryptophycins target beta-tubulin's T5-loop. J.Biol.Chem., 300:107363-107363, 2024 Cited by PubMed: 38735475 DOI: 10.1016/j.jbc.2024.107363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation