8R67
tubulin-cryptophycin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Detyrosinated tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | |
| 2 | B, D | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | |
| 3 | E | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) In PDB | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F | Tubulin tyrosine ligase | polymer | 384 | 44378.5 | 1 | UniProt (A0A8V0Z8P0) Pfam (PF03133) In PDB | Gallus gallus (chicken) | |
| 5 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 6 | F, A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 7 | A, B, C | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 8 | B, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 9 | E, B, C | IMIDAZOLE | non-polymer | 69.1 | 5 | Chemie (IMD) | |||
| 10 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 11 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 12 | D | 2-[(3~{S},10~{R},13~{E},16~{S})-10-[(3-chloranyl-4-methoxy-phenyl)methyl]-6,6-dimethyl-2,5,9,12-tetrakis(oxidanylidene)-16-[(1~{S})-1-[(2~{R},3~{R})-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-en-3-yl]ethanoic acid | non-polymer | 671.1 | 2 | Chemie (Y74) | |||
| 13 | F | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 14 | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 52 (UniProt: A0A8V0Z8P0)
F: 53 - 378 (UniProt: A0A8V0Z8P0)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Ala 4 | - | expression tag |
F: 53 - 378 (UniProt: A0A8V0Z8P0)
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261631.3 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 4694.8 | |
| All* | Total formula weight | 266326.2 |
