7AU5

Tubulin-noscapine-analogue-14e complex

Summary for 7AU5

• Entry DOI: 10.2210/pdb7au5/pdb
• Descriptor: Tubulin alpha-1B chain, GLYCEROL, (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide, ... (14 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265204.11

Authors

Yong, C.,Devine, S.M.,Abel, A.-C.,Muthiah, D.,Gao, X.,Callaghan, R.,Capuano, B.,Steinmetz, M.O.,Prota, A.E.,Scammels, P.J. (deposition date: 2020-11-02, release date: 2021-07-07, Last modification date: 2024-01-31)

• Primary citation: Yong, C.,Devine, S.M.,Abel, A.C.,Tomlins, S.D.,Muthiah, D.,Gao, X.,Callaghan, R.,Steinmetz, M.O.,Prota, A.E.,Capuano, B.,Scammells, P.J.; 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.; Chemmedchem, 16:2882-2894, 2021; PubMed: 34159741; DOI: 10.1002/cmdc.202100363

Experimental method

X-RAY DIFFRACTION (2.2 Å)