5LOV

DZ-2384 tubulin complex

Summary for 5LOV

Related5J2T 4I55
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (12 entities in total)
Functional Keywordscell cycle, tubulin fold, cytoskeleton, microtubule
Biological sourceRattus norvegicus (Norway Rat)
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Cellular locationCytoplasm, cytoskeleton P81947 Q6B856
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight265023.2
Authors
Prota, A.E.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.,Roulston, A. (deposition date: 2016-08-10, release date: 2016-11-30)
Primary citation
Wieczorek, M.,Tcherkezian, J.,Bernier, C.,Prota, A.E.,Chaaban, S.,Rolland, Y.,Godbout, C.,Hancock, M.A.,Arezzo, J.C.,Ocal, O.,Rocha, C.,Olieric, N.,Hall, A.,Ding, H.,Bramoulle, A.,Annis, M.G.,Zogopoulos, G.,Harran, P.G.,Wilkie, T.M.,Brekken, R.A.,Siegel, P.M.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.J.,Roulston, A.
The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.
Sci Transl Med, 8:365ra159-365ra159, 2016
PubMed: 27856798 (PDB entries with the same primary citation)
DOI: 10.1126/scitranslmed.aag1093
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244130.0%2.0%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution