5LOV
DZ-2384 tubulin complex
Summary for 5LOV
Entry DOI | 10.2210/pdb5lov/pdb |
Related | 4I55 5J2T |
Descriptor | Tubulin alpha-1B chain, DZ 2384, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265023.20 |
Authors | Prota, A.E.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.,Roulston, A. (deposition date: 2016-08-10, release date: 2016-11-30, Last modification date: 2024-01-10) |
Primary citation | Wieczorek, M.,Tcherkezian, J.,Bernier, C.,Prota, A.E.,Chaaban, S.,Rolland, Y.,Godbout, C.,Hancock, M.A.,Arezzo, J.C.,Ocal, O.,Rocha, C.,Olieric, N.,Hall, A.,Ding, H.,Bramoulle, A.,Annis, M.G.,Zogopoulos, G.,Harran, P.G.,Wilkie, T.M.,Brekken, R.A.,Siegel, P.M.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.J.,Roulston, A. The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med, 8:365ra159-365ra159, 2016 Cited by PubMed: 27856798DOI: 10.1126/scitranslmed.aag1093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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