7Z7D

Tubulin-Todalam-Vinblastine-complex

Summary for 7Z7D

• Entry DOI: 10.2210/pdb7z7d/pdb
• Related: 5SB3 5SB4 5SB5 5SB6 5SB7
• Descriptor: Tubulin alpha-1B chain, (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265734.72

Authors

Muehlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Roy, B.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. (deposition date: 2022-03-15, release date: 2022-04-27, Last modification date: 2024-01-31)

• Primary citation: Muhlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Roy, B.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O.; Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.; Angew.Chem.Int.Ed.Engl., 61:e202204052-e202204052, 2022; PubMed: 35404502; DOI: 10.1002/anie.202204052

Experimental method

X-RAY DIFFRACTION (2 Å)