5W5E
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![BU of 5w5e by Molmil](/molmil-images/mine/5w5e) | Re-refinement of the pyocin tube structure | Descriptor: | FIIR2 protein | Authors: | Wang, F, Zheng, W, Taylor, N.M, Guerrero-Ferreira, R.C, Leiman, P.G, Egelman, E.H. | Deposit date: | 2017-06-15 | Release date: | 2017-08-16 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit. Structure, 25, 2017
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5ZMD
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![BU of 5zmd by Molmil](/molmil-images/mine/5zmd) | Crystal structure of FTO in complex with m6dA modified ssDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... | Authors: | Zhang, X, Wei, L.H, Luo, J, Xiao, Y, Liu, J, Zhang, W, Zhang, L, Jia, G.F. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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5ZMN
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![BU of 5zmn by Molmil](/molmil-images/mine/5zmn) | Sulfur binding domain and SRA domain of ScoMcrA complexed with phosphorothioated DNA | Descriptor: | DNA (5'-D(*CP*CP*CP*GP*(GS)P*CP*CP*GP*GP*G)-3'), SULFATE ION, Uncharacterized protein McrA | Authors: | Liu, G, Fu, W, Zhang, Z, He, Y, Yu, H, Zhao, Y, Deng, Z, Wu, G, He, X. | Deposit date: | 2018-04-04 | Release date: | 2018-09-26 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structural basis for the recognition of sulfur in phosphorothioated DNA. Nat Commun, 9, 2018
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5Z07
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![BU of 5z07 by Molmil](/molmil-images/mine/5z07) | Crystal structure of centromere protein Cenp-I | Descriptor: | Cenp-I | Authors: | Tian, W, Hu, L.Q, He, X. | Deposit date: | 2017-12-18 | Release date: | 2018-10-31 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment. Nucleic Acids Res., 47, 2019
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5Z10
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![BU of 5z10 by Molmil](/molmil-images/mine/5z10) | Structure of the mechanosensitive Piezo1 channel | Descriptor: | Piezo-type mechanosensitive ion channel component 1 | Authors: | Zhao, Q, Zhou, H, Chi, S, Wang, Y, Wang, J, Geng, J, Wu, K, Liu, W, Zhang, T, Dong, M.-Q, Wang, J, Li, X, Xiao, B. | Deposit date: | 2017-12-22 | Release date: | 2018-01-31 | Last modified: | 2020-01-29 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | Structure and mechanogating mechanism of the Piezo1 channel. Nature, 554, 2018
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5WZ3
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![BU of 5wz3 by Molmil](/molmil-images/mine/5wz3) | Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP) | Descriptor: | NS5 RdRp, ZINC ION | Authors: | Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F. | Deposit date: | 2017-01-16 | Release date: | 2017-03-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J., 36, 2017
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5X29
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5X41
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![BU of 5x41 by Molmil](/molmil-images/mine/5x41) | 3.5A resolution structure of a cobalt energy-coupling factor transporter using LCP method-CbiMQO | Descriptor: | Cobalt ABC transporter ATP-binding protein, Cobalt transport protein CbiM, Uncharacterized protein CbiQ | Authors: | Bao, Z, Qi, X, Zhao, W, Li, D, Zhang, P. | Deposit date: | 2017-02-09 | Release date: | 2017-04-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.47 Å) | Cite: | Structure and mechanism of a group-I cobalt energy coupling factor transporter Cell Res., 27, 2017
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5X93
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![BU of 5x93 by Molmil](/molmil-images/mine/5x93) | Human endothelin receptor type-B in complex with antagonist K-8794 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, CHOLESTEROL, ... | Authors: | Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O. | Deposit date: | 2017-03-05 | Release date: | 2017-08-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog Nat. Struct. Mol. Biol., 24, 2017
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5X9O
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![BU of 5x9o by Molmil](/molmil-images/mine/5x9o) | Crystal structure of the BCL6 BTB domain in complex with Compound 1a | Descriptor: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-03-08 | Release date: | 2017-08-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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5XI7
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![BU of 5xi7 by Molmil](/molmil-images/mine/5xi7) | Crystal structure of T2R-TTL bound with PO-7 | Descriptor: | (6Z)-3-[[2,5-bis(fluoranyl)phenyl]methylidene]-6-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Chu, Y, Wang, Y, Yang, J, Li, W. | Deposit date: | 2017-04-26 | Release date: | 2017-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5Z8O
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5Z9X
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![BU of 5z9x by Molmil](/molmil-images/mine/5z9x) | Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 in complex with an RNA substrate | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*GP*CP*CP*CP*AP*UP*UP*AP*G)-3'), SULFATE ION, ... | Authors: | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Gan, J, Cao, C, Huang, Y, Chen, X, Ma, J. | Deposit date: | 2018-02-05 | Release date: | 2018-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5ZBG
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![BU of 5zbg by Molmil](/molmil-images/mine/5zbg) | |
5ZMM
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![BU of 5zmm by Molmil](/molmil-images/mine/5zmm) | Structure of the Type IV phosphorothioation-dependent restriction endonuclease ScoMcrA | Descriptor: | SULFATE ION, Uncharacterized protein McrA, ZINC ION | Authors: | Liu, G, Fu, W, Zhang, Z, He, Y, Yu, H, Zhao, Y, Deng, Z, Wu, G, He, X. | Deposit date: | 2018-04-04 | Release date: | 2018-09-26 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural basis for the recognition of sulfur in phosphorothioated DNA. Nat Commun, 9, 2018
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5ZOF
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![BU of 5zof by Molmil](/molmil-images/mine/5zof) | Crystal Structure of D181A/R192F hFen1 in complex with DNA | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ... | Authors: | Han, W, Hua, Y, Zhao, Y. | Deposit date: | 2018-04-13 | Release date: | 2019-01-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.249 Å) | Cite: | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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5Z6C
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5Z9Z
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![BU of 5z9z by Molmil](/molmil-images/mine/5z9z) | The C-terminal RRM domain of Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 (E329A/E330A/E332A) | Descriptor: | CITRATE ANION, Small RNA degrading nuclease 1 | Authors: | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Cao, C, Gan, J, Huang, Y, Chen, X, Ma, J. | Deposit date: | 2018-02-05 | Release date: | 2018-06-27 | Last modified: | 2018-10-03 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5ZHN
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![BU of 5zhn by Molmil](/molmil-images/mine/5zhn) | Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | Descriptor: | N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Zhong, W, Pasunooti, K.K, Balamkundu, S, Wong, Y.W, Nah, Q, Liu, C.F, Lescar, J, Dedon, P.C. | Deposit date: | 2018-03-13 | Release date: | 2019-03-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. J.Med.Chem., 62, 2019
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5ZHL
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![BU of 5zhl by Molmil](/molmil-images/mine/5zhl) | Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor | Descriptor: | N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Zhong, W, Pasunooti, K.K, Balamkundu, S, Wong, Y.W, Nah, Q, Liu, C.F, Lescar, J, Dedon, P.C. | Deposit date: | 2018-03-13 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. J.Med.Chem., 62, 2019
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5YX9
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5Z2T
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![BU of 5z2t by Molmil](/molmil-images/mine/5z2t) | Crystal structure of DNA-bound DUX4-HD2 | Descriptor: | 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3', Double homeobox protein 4 | Authors: | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | Deposit date: | 2018-01-04 | Release date: | 2018-04-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.623 Å) | Cite: | Structural basis of DUX4/IGH-driven transactivation. Leukemia, 32, 2018
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5ZHJ
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![BU of 5zhj by Molmil](/molmil-images/mine/5zhj) | Crystal structure of TrmD from Mycobacterium tuberculosis in complex with S-adenosyl homocysteine (SAH) | Descriptor: | GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Zhong, W, Pasunooti, K.K, Balamkundu, S, Wong, Y.W, Nah, Q, Liu, C.F, Lescar, J, Dedon, P.C. | Deposit date: | 2018-03-13 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. J.Med.Chem., 62, 2019
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5ZOD
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![BU of 5zod by Molmil](/molmil-images/mine/5zod) | Crystal Structure of hFen1 in apo form | Descriptor: | Flap endonuclease 1, MAGNESIUM ION, POTASSIUM ION | Authors: | Han, W, Hua, Y, Zhao, Y. | Deposit date: | 2018-04-13 | Release date: | 2019-01-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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5YYC
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![BU of 5yyc by Molmil](/molmil-images/mine/5yyc) | Crystal structure of alanine racemase from Bacillus pseudofirmus (OF4) | Descriptor: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Dong, H, Hu, T.T, He, G.Z, Lu, D.R, Qi, J.X, Dou, Y.S, Long, W, He, X, Su, D, Ju, J.S. | Deposit date: | 2017-12-08 | Release date: | 2019-01-02 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4. Biochem. Biophys. Res. Commun., 497, 2018
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