5ZMD

Crystal structure of FTO in complex with m6dA modified ssDNA

Summary for 5ZMD

• Entry DOI: 10.2210/pdb5zmd/pdb
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: rna demetheylase fto, m6a, substrate preference, rna binding protein, oxidoreductase-dna complex, oxidoreductase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 224936.28

Authors

Zhang, X.,Wei, L.H.,Luo, J.,Xiao, Y.,Liu, J.,Zhang, W.,Zhang, L.,Jia, G.F. (deposition date: 2018-04-02, release date: 2019-04-10, Last modification date: 2023-11-22)

• Primary citation: Zhang, X.,Wei, L.H.,Wang, Y.,Xiao, Y.,Liu, J.,Zhang, W.,Yan, N.,Amu, G.,Tang, X.,Zhang, L.,Jia, G.; Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.; Proc. Natl. Acad. Sci. U.S.A., 116:2919-2924, 2019; PubMed: 30718435; DOI: 10.1073/pnas.1820574116

Experimental method

X-RAY DIFFRACTION (3.3 Å)