5ZMD

Crystal structure of FTO in complex with m6dA modified ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001659	biological_process	temperature homeostasis
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006307	biological_process	DNA alkylation repair
A	0008198	molecular_function	ferrous iron binding
A	0010883	biological_process	regulation of lipid storage
A	0016180	biological_process	snRNA processing
A	0016491	molecular_function	oxidoreductase activity
A	0016607	cellular_component	nuclear speck
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0016740	molecular_function	transferase activity
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0040014	biological_process	regulation of multicellular organism growth
A	0042245	biological_process	RNA repair
A	0044065	biological_process	regulation of respiratory system process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0060612	biological_process	adipose tissue development
A	0061157	biological_process	mRNA destabilization
A	0070350	biological_process	regulation of white fat cell proliferation
A	0090335	biological_process	regulation of brown fat cell differentiation
A	1990931	molecular_function	mRNA N6-methyladenosine dioxygenase activity
A	1990984	molecular_function	tRNA demethylase activity
C	0001659	biological_process	temperature homeostasis
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006307	biological_process	DNA alkylation repair
C	0008198	molecular_function	ferrous iron binding
C	0010883	biological_process	regulation of lipid storage
C	0016180	biological_process	snRNA processing
C	0016491	molecular_function	oxidoreductase activity
C	0016607	cellular_component	nuclear speck
C	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
C	0016740	molecular_function	transferase activity
C	0035515	molecular_function	oxidative RNA demethylase activity
C	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
C	0040014	biological_process	regulation of multicellular organism growth
C	0042245	biological_process	RNA repair
C	0044065	biological_process	regulation of respiratory system process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0060612	biological_process	adipose tissue development
C	0061157	biological_process	mRNA destabilization
C	0070350	biological_process	regulation of white fat cell proliferation
C	0090335	biological_process	regulation of brown fat cell differentiation
C	1990931	molecular_function	mRNA N6-methyladenosine dioxygenase activity
C	1990984	molecular_function	tRNA demethylase activity
E	0001659	biological_process	temperature homeostasis
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006307	biological_process	DNA alkylation repair
E	0008198	molecular_function	ferrous iron binding
E	0010883	biological_process	regulation of lipid storage
E	0016180	biological_process	snRNA processing
E	0016491	molecular_function	oxidoreductase activity
E	0016607	cellular_component	nuclear speck
E	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
E	0016740	molecular_function	transferase activity
E	0035515	molecular_function	oxidative RNA demethylase activity
E	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
E	0040014	biological_process	regulation of multicellular organism growth
E	0042245	biological_process	RNA repair
E	0044065	biological_process	regulation of respiratory system process
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0060612	biological_process	adipose tissue development
E	0061157	biological_process	mRNA destabilization
E	0070350	biological_process	regulation of white fat cell proliferation
E	0090335	biological_process	regulation of brown fat cell differentiation
E	1990931	molecular_function	mRNA N6-methyladenosine dioxygenase activity
E	1990984	molecular_function	tRNA demethylase activity
G	0001659	biological_process	temperature homeostasis
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006307	biological_process	DNA alkylation repair
G	0008198	molecular_function	ferrous iron binding
G	0010883	biological_process	regulation of lipid storage
G	0016180	biological_process	snRNA processing
G	0016491	molecular_function	oxidoreductase activity
G	0016607	cellular_component	nuclear speck
G	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
G	0016740	molecular_function	transferase activity
G	0035515	molecular_function	oxidative RNA demethylase activity
G	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
G	0040014	biological_process	regulation of multicellular organism growth
G	0042245	biological_process	RNA repair
G	0044065	biological_process	regulation of respiratory system process
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
G	0060612	biological_process	adipose tissue development
G	0061157	biological_process	mRNA destabilization
G	0070350	biological_process	regulation of white fat cell proliferation
G	0090335	biological_process	regulation of brown fat cell differentiation
G	1990931	molecular_function	mRNA N6-methyladenosine dioxygenase activity
G	1990984	molecular_function	tRNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 1001

Chain	Residue
A	HIS231
A	ASP233
A	HIS307
A	OGA1002

---

site_id	AC2
Number of Residues	12
Details	binding site for residue OGA A 1002

Chain	Residue
A	HIS307
A	VAL309
A	ARG316
A	SER318
A	THR320
A	ARG322
A	MN1001
A	ARG96
A	ASN205
A	HIS231
A	ASP233
A	TYR295

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MN C 1001

Chain	Residue
C	HIS231
C	ASP233
C	HIS307
C	OGA1002

---

site_id	AC4
Number of Residues	12
Details	binding site for residue OGA C 1002

Chain	Residue
C	ARG96
C	ASN205
C	HIS231
C	ASP233
C	VAL272
C	TYR295
C	HIS307
C	VAL309
C	ARG316
C	SER318
C	ARG322
C	MN1001

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MN E 1001

Chain	Residue
E	HIS231
E	ASP233
E	HIS307
E	OGA1002

---

site_id	AC6
Number of Residues	12
Details	binding site for residue OGA E 1002

Chain	Residue
E	ARG96
E	ASN205
E	HIS231
E	TYR295
E	HIS307
E	VAL309
E	ARG316
E	SER318
E	THR320
E	ARG322
E	MN1001
F	6MA5

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MN G 1001

Chain	Residue
G	HIS231
G	ASP233
G	HIS307
G	OGA1002

---

site_id	AC8
Number of Residues	11
Details	binding site for residue OGA G 1002

Chain	Residue
G	ARG96
G	ASN205
G	HIS231
G	VAL272
G	TYR295
G	HIS307
G	VAL309
G	ARG316
G	SER318
G	ARG322
G	MN1001

---

site_id	AC9
Number of Residues	18
Details	binding site for Di-peptide GLU C 375 and ARG C 449

Chain	Residue
C	HIS371
C	ASN372
C	GLU373
C	VAL374
C	PHE376
C	GLU377
C	LEU379
C	ARG380
C	TRP407
C	ARG445
C	GLN446
C	ASN447
C	LEU448
C	ARG450
C	GLU451
C	TRP452
C	HIS453
C	PHE487

---

site_id	AD1
Number of Residues	16
Details	binding site for Di-nucleotide DT D 4 and 6MA D 5

Chain	Residue
B	DT4
C	ILE85
C	LYS86
C	ARG96
C	TYR108
C	LEU109
C	ASN110
C	VAL228
C	SER229
C	TRP230
C	HIS231
C	GLU234
C	LYS306
C	ARG322
D	DC3
D	DT6

---

site_id	AD2
Number of Residues	16
Details	binding site for Di-nucleotide 6MA D 5 and DT D 6

Chain	Residue
C	LYS88
C	ARG96
C	TYR108
C	LEU109
C	LYS216
C	VAL228
C	SER229
C	TRP230
C	HIS231
C	GLU234
C	LYS306
C	ARG322
D	DT4
D	DA7
B	DT6
C	ILE85

---

site_id	AD3
Number of Residues	9
Details	binding site for Di-peptide LYS E 107 and GLU E 377

Chain	Residue
E	TYR106
E	TYR108
E	ARG112
E	ASN235
E	GLU373
E	GLU375
E	PHE376
E	TRP378
E	GLN381

---

site_id	AD4
Number of Residues	8
Details	binding site for Di-peptide LEU E 464 and LYS E 469

Chain	Residue
E	ILE460
E	ARG462
E	THR463
E	PRO465
E	ALA466
E	GLN468
E	PRO470
E	GLU471

---

site_id	AD5
Number of Residues	15
Details	binding site for Di-nucleotide DT F 4 and 6MA F 5

Chain	Residue
E	LYS86
E	ARG96
E	TYR106
E	TYR108
E	LEU109
E	ASN110
E	VAL228
E	SER229
E	TRP230
E	HIS231
E	GLU234
E	OGA1002
F	DC3
F	DT6
H	DT4

---

site_id	AD6
Number of Residues	17
Details	binding site for Di-nucleotide 6MA F 5 and DT F 6

Chain	Residue
E	ILE85
E	LYS86
E	LYS88
E	ARG96
E	TYR106
E	TYR108
E	LEU109
E	LYS216
E	VAL228
E	SER229
E	TRP230
E	HIS231
E	GLU234
E	OGA1002
F	DT4
F	DA7
H	DT6

---

site_id	AD7
Number of Residues	14
Details	binding site for Di-nucleotide DT H 4 and 6MA H 5

Chain	Residue
F	DT4
G	ILE85
G	LYS86
G	ARG96
G	TYR108
G	LEU109
G	ASN110
G	VAL228
G	SER229
G	TRP230
G	HIS231
G	GLU234
H	DC3
H	DT6

---

site_id	AD8
Number of Residues	14
Details	binding site for Di-nucleotide 6MA H 5 and DT H 6

Chain	Residue
F	DT6
G	ILE85
G	LYS86
G	ARG96
G	TYR108
G	LEU109
G	LYS216
G	VAL228
G	SER229
G	TRP230
G	HIS231
G	GLU234
H	DT4
H	DA7

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Loop L1; predicted to block binding of double-stranded DNA or RNA","evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---