5ZMD
Crystal structure of FTO in complex with m6dA modified ssDNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 463 | 53312.2 | 4 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) | Homo sapiens (Human) | Fat mass and obesity-associated protein |
| 2 | B, D, F, H (B, D, F, H) | DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3') | polymer | 9 | 2719.8 | 4 | DNA launch vector pDE-GFP2 | ||
| 3 | I, K, M, O (A, C, E, G) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 4 | J, L, N, P (A, C, E, G) | N-OXALYLGLYCINE | non-polymer | 147.1 | 4 | Chemie (OGA) | |||
| 5 | Q, R, S, T, U (A, C, D, E, G) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 37 - 499 (UniProt: Q9C0B1)
| PDB | External Database | Details |
|---|---|---|
| Lys 86 | Gln 86 | engineered mutation |
| Lys 306 | Gln 306 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 224128.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 808.1 | |
| All* | Total formula weight | 224936.3 |
