Crystal Structure of D181A/R192F hFen1 in complex with DNA

Summary for 5ZOF

DescriptorFlap endonuclease 1, DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ... (6 entities in total)
Functional Keywordsflap endonuclease: gap endonuclease: methylation: posttranslational modification, dna binding protein, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight49838.3
Han, W.,Hua, Y.,Zhao, Y. (deposition date: 2018-04-13, release date: 2019-01-30)
Primary citation
Xu, H.,Shi, R.,Han, W.,Cheng, J.,Xu, X.,Cheng, K.,Wang, L.,Tian, B.,Zheng, L.,Shen, B.,Hua, Y.,Zhao, Y.
Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46:11315-11325, 2018
PubMed: 30295841 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gky911
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26970 0.4% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5zof
no rotation
Molmil generated image of 5zof
rotated about x axis by 90°
Molmil generated image of 5zof
rotated about y axis by 90°