5XI7

Crystal structure of T2R-TTL bound with PO-7

Summary for 5XI7

• Entry DOI: 10.2210/pdb5xi7/pdb
• Descriptor: Tubulin alpha chain, (6Z)-3-[[2,5-bis(fluoranyl)phenyl]methylidene]-6-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]piperazine-2,5-dione, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, microtubule, colchicine, stathmin, structural protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton : A0A0R4I993 A0A0R4I995; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 269969.12

Authors

Chu, Y.,Wang, Y.,Yang, J.,Li, W. (deposition date: 2017-04-26, release date: 2017-10-18, Last modification date: 2024-03-27)

• Primary citation: Chu, Y.,Wang, Y.,Yang, J.,Li, W.; Synthesis, biological evaluation and X-ray structure of anti-microtubule agents; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.99 Å)