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PDB: 48 件

7F58
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Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex
分子名称: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
登録日2021-06-21
公開日2021-11-03
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F54
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Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex
分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
登録日2021-06-21
公開日2021-11-03
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F55
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Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex
分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
登録日2021-06-21
公開日2021-11-03
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F53
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Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex
分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
登録日2021-06-21
公開日2021-11-03
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7C7Q
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Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state
分子名称: (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ...
著者Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y.
登録日2020-05-26
公開日2020-07-01
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
7C7S
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Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state.
分子名称: (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ...
著者Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y.
登録日2020-05-26
公開日2020-07-01
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
6LB8
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Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex
分子名称: Calcium uptake protein 2, mitochondrial, Endolysin,Calcium uptake protein 1
著者Wu, W, Shen, Q, Zheng, J, Jia, Z.
登録日2019-11-13
公開日2020-07-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.283 Å)
主引用文献The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.
Embo J., 39, 2020
6LB7
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Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex
分子名称: CALCIUM ION, Calcium uptake protein 1, mitochondrial, ...
著者Wu, W, Shen, Q, Zheng, J, Jia, Z.
登録日2019-11-13
公開日2020-07-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.
Embo J., 39, 2020
7EB2
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Cryo-EM structure of human GABA(B) receptor-Gi protein complex
分子名称: (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
著者Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J.
登録日2021-03-08
公開日2021-05-05
最終更新日2021-07-07
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of GABA B receptor-G i protein coupling.
Nature, 594, 2021
7BV1
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Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
分子名称: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ...
著者Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
登録日2020-04-09
公開日2020-04-22
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7BV2
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The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)
分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
著者Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
登録日2020-04-09
公開日2020-04-22
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7CX4
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Cryo-EM structure of the Evatanepag-bound EP2-Gs complex
分子名称: 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
登録日2020-09-01
公開日2021-05-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
7CX3
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Cryo-EM structure of the Taprenepag-bound EP2-Gs complex
分子名称: 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
登録日2020-09-01
公開日2021-05-05
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
7CX2
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Cryo-EM structure of the PGE2-bound EP2-Gs complex
分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
登録日2020-09-01
公開日2021-05-05
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
7XA3
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Cryo-EM structure of the CCL2 bound CCR2-Gi complex
分子名称: C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H.
登録日2022-03-17
公開日2022-08-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
7X9Y
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Cryo-EM structure of the apo CCR3-Gi complex
分子名称: C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H.
登録日2022-03-16
公開日2022-08-24
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
8WU1
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Cryo-EM structure of CB1-beta-arrestin1 complex
分子名称: Beta-arrestin-1, Cannabinoid receptor 1,Vasopressin V2 receptor, Fab30 heavy chain, ...
著者Liao, Y, Zhang, H, Shen, Q, Cai, C.
登録日2023-10-19
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure of CB1-beta-arrestin1 complex
to be published
7D76
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Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex
分子名称: (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ...
著者Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J.
登録日2020-10-03
公開日2021-02-03
最終更新日2021-02-10
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex.
Nature, 589, 2021
7D77
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Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex
分子名称: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ...
著者Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J.
登録日2020-10-03
公開日2021-02-03
最終更新日2021-02-10
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex.
Nature, 589, 2021
7XW9
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Cryo-EM structure of the TRH-bound human TRHR-Gq complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y.
登録日2022-05-26
公開日2022-12-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
7EWQ
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Structure of Mumps virus nucleocapsid ring
分子名称: Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
著者Su, X, Shen, Q, Shan, H.
登録日2021-05-25
公開日2021-06-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural plasticity of mumps virus nucleocapsids for genome protection and condensation
To Be Published
7Y36
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Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ...
著者Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
登録日2022-06-10
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
7Y35
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Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
登録日2022-06-09
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
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223532

件を2024-08-07に公開中

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