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7CX3

Cryo-EM structure of the Taprenepag-bound EP2-Gs complex

Summary for 7CX3
Entry DOI10.2210/pdb7cx3/pdb
EMDB information30490
DescriptorProstaglandin E2 receptor EP2 subtype, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywordsgpcr, ep2, complex, taprenepag, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains5
Total formula weight147198.13
Authors
Primary citationQu, C.,Mao, C.,Xiao, P.,Shen, Q.,Zhong, Y.N.,Yang, F.,Shen, D.D.,Tao, X.,Zhang, H.,Yan, X.,Zhao, R.J.,He, J.,Guan, Y.,Zhang, C.,Hou, G.,Zhang, P.J.,Hou, G.,Li, Z.,Yu, X.,Chai, R.J.,Guan, Y.F.,Sun, J.P.,Zhang, Y.
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7:-, 2021
Cited by
PubMed: 33811074
DOI: 10.1126/sciadv.abf1268
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.8 Å)
Structure validation

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