7F58

Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex

Summary for 7F58

• Entry DOI: 10.2210/pdb7f58/pdb
• EMDB information: 31456 31457 31458 31461
• Descriptor: Melanocortin receptor 4, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (8 entities in total)
• Functional Keywords: single particle, membrane protein, class a g-protein-coupled receptors
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 164268.49

Authors

Zhang, H.,Chen, L.,Mao, C.,Shen, Q.,Yang, D.,Shen, D.,Qin, J. (deposition date: 2021-06-21, release date: 2021-11-03, Last modification date: 2022-02-16)

• Primary citation: Zhang, H.,Chen, L.N.,Yang, D.,Mao, C.,Shen, Q.,Feng, W.,Shen, D.D.,Dai, A.,Xie, S.,Zhou, Y.,Qin, J.,Sun, J.P.,Scharf, D.H.,Hou, T.,Zhou, T.,Wang, M.W.,Zhang, Y.; Structural insights into ligand recognition and activation of the melanocortin-4 receptor.; Cell Res., 31:1163-1175, 2021; PubMed: 34433901; DOI: 10.1038/s41422-021-00552-3

Experimental method

ELECTRON MICROSCOPY (3.1 Å)