7DOI
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7DOK
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7XTQ
| Cryo-EM structure of the R399-bound GPBAR-Gs complex | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | Deposit date: | 2022-05-17 | Release date: | 2022-07-06 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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8FW9
| Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry | Descriptor: | NLR family CARD domain-containing protein 4 | Authors: | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | Deposit date: | 2023-01-20 | Release date: | 2024-01-03 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (4.46 Å) | Cite: | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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8FVU
| Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1, Lethal factor,Type III secretion system protein, ... | Authors: | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | Deposit date: | 2023-01-19 | Release date: | 2024-01-03 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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8HEV
| C12 portal in HCMV B-capsid | Descriptor: | Portal protein, Unknown peptide | Authors: | Li, Z, Yu, X. | Deposit date: | 2022-11-08 | Release date: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
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8HEU
| C12 portal in HCMV A-capsid | Descriptor: | Portal protein | Authors: | Li, Z, Yu, X. | Deposit date: | 2022-11-08 | Release date: | 2023-04-26 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
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8HQE
| Cryo-EM structure of the apo-GPR132-Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HVI
| Activation mechanism of GPR132 by compound NOX-6-7 | Descriptor: | 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQN
| Activation mechanism of GPR132 by 9(S)-HODE | Descriptor: | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQM
| Activation mechanism of GPR132 by NPGLY | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HEX
| C5 portal vertex in HCMV B-capsid | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2022-11-08 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
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8HEY
| One CVSC-binding penton vertex in HCMV B-capsid | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2022-11-09 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nat Commun, 14, 2023
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7TRY
| Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein | Descriptor: | Corticotropin-releasing factor receptor 2, G protein gamma subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E. | Deposit date: | 2022-01-31 | Release date: | 2022-11-09 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13, 2022
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7TS0
| Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein | Descriptor: | Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Dominant negative Go alpha subunit, G protein gamma subunit, ... | Authors: | Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E. | Deposit date: | 2022-01-31 | Release date: | 2022-11-09 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13, 2022
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7WUJ
| Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | Descriptor: | Adhesion G-protein coupled receptor G4,Uncharacterized protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Guo, S.C, Huang, S.M, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | Deposit date: | 2022-02-08 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
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7WUI
| Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | Descriptor: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Guo, S.C, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | Deposit date: | 2022-02-08 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
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7WUQ
| Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | Descriptor: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Q.T, Guo, S.C, Xiao, P, Sun, J.P, Yu, X, Gou, L, Kong, L.L, Zhang, L. | Deposit date: | 2022-02-09 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
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7DFB
| Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DF9
| Crystal of Arrestin2-V2Rpp-1-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFA
| Crystal of Arrestin2-V2Rpp-4-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFC
| Crystal of Arrestin2-V2Rpp-3-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7ETJ
| C5 portal vertex in the partially-enveloped virion capsid | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-13 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ET2
| Human Cytomegalovirus, C12 portal | Descriptor: | Portal protein | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-12 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ETM
| C6 portal vertex in the enveloped virion capsid | Descriptor: | Portal protein | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-13 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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