7WUQ

Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4

Summary for 7WUQ

• Entry DOI: 10.2210/pdb7wuq/pdb
• EMDB information: 32838
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: gpcr, adgrg2, adgrg4, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 184067.07

Authors

He, Q.T.,Guo, S.C.,Xiao, P.,Sun, J.P.,Yu, X.,Gou, L.,Kong, L.L.,Zhang, L. (deposition date: 2022-02-09, release date: 2022-04-27, Last modification date: 2022-05-11)

• Primary citation: Xiao, P.,Guo, S.,Wen, X.,He, Q.T.,Lin, H.,Huang, S.M.,Gou, L.,Zhang, C.,Yang, Z.,Zhong, Y.N.,Yang, C.C.,Li, Y.,Gong, Z.,Tao, X.N.,Yang, Z.S.,Lu, Y.,Li, S.L.,He, J.Y.,Wang, C.,Zhang, L.,Kong, L.,Sun, J.P.,Yu, X.; Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.; Nature, 604:771-778, 2022; PubMed: 35418677; DOI: 10.1038/s41586-022-04590-8

Experimental method

ELECTRON MICROSCOPY (2.9 Å)