8FW9
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Summary for 8FW9
Entry DOI | 10.2210/pdb8fw9/pdb |
EMDB information | 29498 |
Descriptor | NLR family CARD domain-containing protein 4 (1 entity in total) |
Functional Keywords | nlrc4, naip, inflammasome, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 351082.97 |
Authors | Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. (deposition date: 2023-01-20, release date: 2024-01-03, Last modification date: 2024-01-31) |
Primary citation | Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31:82-91, 2024 Cited by PubMed: 38177670DOI: 10.1038/s41594-023-01143-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.46 Å) |
Structure validation
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