Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8FW9

Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0002218	biological_process	activation of innate immune response
A	0002221	biological_process	pattern recognition receptor signaling pathway
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0010954	biological_process	positive regulation of protein processing
A	0016045	biological_process	detection of bacterium
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0046456	biological_process	icosanoid biosynthetic process
A	0050729	biological_process	positive regulation of inflammatory response
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051260	biological_process	protein homooligomerization
A	0061133	molecular_function	endopeptidase activator activity
A	0061702	cellular_component	canonical inflammasome complex
A	0070269	biological_process	pyroptotic inflammatory response
A	0072557	cellular_component	IPAF inflammasome complex
A	0089720	molecular_function	caspase binding
A	0097202	biological_process	obsolete activation of cysteine-type endopeptidase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0002218	biological_process	activation of innate immune response
B	0002221	biological_process	pattern recognition receptor signaling pathway
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0006954	biological_process	inflammatory response
B	0010954	biological_process	positive regulation of protein processing
B	0016045	biological_process	detection of bacterium
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0042742	biological_process	defense response to bacterium
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0045087	biological_process	innate immune response
B	0046456	biological_process	icosanoid biosynthetic process
B	0050729	biological_process	positive regulation of inflammatory response
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051260	biological_process	protein homooligomerization
B	0061133	molecular_function	endopeptidase activator activity
B	0061702	cellular_component	canonical inflammasome complex
B	0070269	biological_process	pyroptotic inflammatory response
B	0072557	cellular_component	IPAF inflammasome complex
B	0089720	molecular_function	caspase binding
B	0097202	biological_process	obsolete activation of cysteine-type endopeptidase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0002218	biological_process	activation of innate immune response
C	0002221	biological_process	pattern recognition receptor signaling pathway
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006915	biological_process	apoptotic process
C	0006954	biological_process	inflammatory response
C	0010954	biological_process	positive regulation of protein processing
C	0016045	biological_process	detection of bacterium
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0045087	biological_process	innate immune response
C	0046456	biological_process	icosanoid biosynthetic process
C	0050729	biological_process	positive regulation of inflammatory response
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051260	biological_process	protein homooligomerization
C	0061133	molecular_function	endopeptidase activator activity
C	0061702	cellular_component	canonical inflammasome complex
C	0070269	biological_process	pyroptotic inflammatory response
C	0072557	cellular_component	IPAF inflammasome complex
C	0089720	molecular_function	caspase binding
C	0097202	biological_process	obsolete activation of cysteine-type endopeptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	939
Details	Domain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	69
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	69
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	69
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	75
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	69
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	66
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	72
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	81
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	60
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	66
Details	Repeat: {"description":"LRR 12"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	609
Details	Region: {"description":"Nucleotide-binding domain (NBD)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	321
Details	Region: {"description":"Winged-helix domain (WHD)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q3UP24","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)