8W8R
Cryo-EM structure of the AA-14-bound GPR101-Gs complex
Summary for 8W8R
Entry DOI | 10.2210/pdb8w8r/pdb |
EMDB information | 37357 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Probable G-protein coupled receptor 101, ... (6 entities in total) |
Functional Keywords | gpcr, orphan receptor, gpr101, constitutive activity, cryo-em, structural protein, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 173576.48 |
Authors | Sun, J.P.,Yu, X.,Gao, N.,Yang, F.,Wang, J.Y.,Yang, Z.,Guan, Y.,Wang, G.P. (deposition date: 2023-09-04, release date: 2024-01-03, Last modification date: 2024-04-10) |
Primary citation | Yang, Z.,Wang, J.Y.,Yang, F.,Zhu, K.K.,Wang, G.P.,Guan, Y.,Ning, S.L.,Lu, Y.,Li, Y.,Zhang, C.,Zheng, Y.,Zhou, S.H.,Wang, X.W.,Wang, M.W.,Xiao, P.,Yi, F.,Zhang, C.,Zhang, P.J.,Xu, F.,Liu, B.H.,Zhang, H.,Yu, X.,Gao, N.,Sun, J.P. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20:484-492, 2024 Cited by PubMed: 37945893DOI: 10.1038/s41589-023-01456-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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