8W8R
Cryo-EM structure of the AA-14-bound GPR101-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit | polymer | 362 | 42010.7 | 1 | UniProt (P63096) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 341 | 37429.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (R) | Probable G-protein coupled receptor 101 | polymer | 508 | 56774.9 | 1 | UniProt (Q96P66) Pfam (PF00001) | Homo sapiens (human) | |
| 4 | D (S) | Scfv16 | polymer | 285 | 30363.0 | 1 | Homo sapiens (human) | ||
| 5 | E (Y) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F, G (R) | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea | non-polymer | 311.3 | 2 | Chemie (U7D) |
Sequence modifications
A: 18 - 34 (UniProt: P63096)
A: 35 - 394 (PDB: 8W8R)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 172953.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 622.6 | |
| All* | Total formula weight | 173576.5 |
