8W8Q

Cryo-EM structure of the GPR101-Gs complex

Summary for 8W8Q

Entry DOI	10.2210/pdb8w8q/pdb
EMDB information	37356
Descriptor	Soluble cytochrome b562,Probable G-protein coupled receptor 101, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
Functional Keywords	gpcr, orphan receptor, gpr101, constitutive activity, cryo-em, structural protein, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	5
Total formula weight	176834.77
Authors	Sun, J.P.,Gao, N.,Yu, X.,Wang, G.P.,Yang, F.,Wang, J.Y.,Yang, Z.,Guan, Y. (deposition date: 2023-09-04, release date: 2024-01-03, Last modification date: 2024-04-10)
Primary citation	Yang, Z.,Wang, J.Y.,Yang, F.,Zhu, K.K.,Wang, G.P.,Guan, Y.,Ning, S.L.,Lu, Y.,Li, Y.,Zhang, C.,Zheng, Y.,Zhou, S.H.,Wang, X.W.,Wang, M.W.,Xiao, P.,Yi, F.,Zhang, C.,Zhang, P.J.,Xu, F.,Liu, B.H.,Zhang, H.,Yu, X.,Gao, N.,Sun, J.P. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20:484-492, 2024 Cited by PubMed: 37945893 DOI: 10.1038/s41589-023-01456-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.89 Å)

Structure validation