8FW2

Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry

Summary for 8FW2

• Entry DOI: 10.2210/pdb8fw2/pdb
• EMDB information: 29496
• Descriptor: NLR family CARD domain-containing protein 4 (1 entity in total)
• Functional Keywords: nlrc4, naip, inflammasome, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 351082.97

Authors

Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. (deposition date: 2023-01-20, release date: 2024-01-03, Last modification date: 2024-01-31)

• Primary citation: Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S.; Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.; Nat.Struct.Mol.Biol., 31:82-91, 2024; PubMed: 38177670; DOI: 10.1038/s41594-023-01143-z

Experimental method

ELECTRON MICROSCOPY (3.8 Å)