8FVU

Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)

Summary for 8FVU

• Entry DOI: 10.2210/pdb8fvu/pdb
• EMDB information: 29493
• Descriptor: Baculoviral IAP repeat-containing protein 1, NLR family CARD domain-containing protein 4, Lethal factor,Type III secretion system protein, ... (5 entities in total)
• Functional Keywords: nlrc4, naip, inflammasome, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 320960.13

Authors

Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S. (deposition date: 2023-01-19, release date: 2024-01-03, Last modification date: 2024-01-31)

• Primary citation: Matico, R.E.,Yu, X.,Miller, R.,Somani, S.,Ricketts, M.D.,Kumar, N.,Steele, R.A.,Medley, Q.,Berger, S.,Faustin, B.,Sharma, S.; Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.; Nat.Struct.Mol.Biol., 31:82-91, 2024; PubMed: 38177670; DOI: 10.1038/s41594-023-01143-z

Experimental method

ELECTRON MICROSCOPY (3.6 Å)