8W8S

Cryo-EM structure of the AA14-bound GPR101 complex

Summary for 8W8S

Entry DOI	10.2210/pdb8w8s/pdb
EMDB information	37358
Descriptor	Probable G-protein coupled receptor 101, 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea (2 entities in total)
Functional Keywords	gpcr, orphan receptor, gpr101, constitutive activity, cryo-em, structural protein, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57397.58
Authors	Sun, J.P.,Yu, X.,Gao, N.,Yang, F.,Wang, J.Y.,Yang, Z.,Guan, Y.,Wang, G.P. (deposition date: 2023-09-04, release date: 2024-01-03, Last modification date: 2024-04-10)
Primary citation	Yang, Z.,Wang, J.Y.,Yang, F.,Zhu, K.K.,Wang, G.P.,Guan, Y.,Ning, S.L.,Lu, Y.,Li, Y.,Zhang, C.,Zheng, Y.,Zhou, S.H.,Wang, X.W.,Wang, M.W.,Xiao, P.,Yi, F.,Zhang, C.,Zhang, P.J.,Xu, F.,Liu, B.H.,Zhang, H.,Yu, X.,Gao, N.,Sun, J.P. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20:484-492, 2024 Cited by PubMed: 37945893 DOI: 10.1038/s41589-023-01456-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation