2V2W

T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT

Replaces:  2BSU

Summary for 2V2W

Related1AKJ 1AO7 1AQD 1B0G 1B0R 1BD2 1DUY 1DUZ 1EEY 1EEZ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1JF1 1JHT 1LP9 1OGA 1P7Q 1QEW 1QR1 1QRN 1QSE 1QSF 1S8D 1S9W 1S9X 1S9Y 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TVB 1TVH 1UR7 2AV1 2AV7 2BNQ 2BNR 2BSU 2BSV 2C7U 2CLR 2GJ6 2JCC 2UWE 3HLA 1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1C16 1CE6 1CG9 1DE4 1E27 1E28 1EFX 1EXU 1GZP 1GZQ 1HSA 1HSB 1IM9 1JGD 1JGE 1JNJ 1K5N 1KPR 1KTL 1LDS 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGT 1ONQ 1PY4 1Q94 1QLF 1QQD 1QVO 1R3H 1SYS 1SYV 1TMC 1UQS 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZS8 1ZSD 1ZT4 2A83 2AK4 2AXF 2AXG 2BCK 2BSR 2BSS 2BST 2BVQ 2CII 2CIK 2D31 2ESV 2F74 2F8O 2H26 2HJK 2HJL 2HLA 2V2X
DescriptorHLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2 MICROGLOBULIN, HIV P17, ... (4 entities in total)
Functional Keywordsimmunoglobulin domain, complex (antigen-peptide), tcr, hiv, mhc, aids, mhc i, hla-a2, membrane, host-virus interaction, pyrrolidone carboxylic acid, immune system, ubl conjugation, immune response, disease mutation, polymorphism, glycoprotein, transmembrane
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted P61769
Total number of polymer chains6
Total molecular weight89623.55
Authors
Lee, J.K.,Stewart-Jones, G.,Dong, T.,Harlos, K.,Di Gleria, K.,Dorrell, L.,Douek, D.C.,Van Der Merwe, P.A.,Jones, E.Y.,Mcmichael, A.J. (deposition date: 2007-06-07, release date: 2007-11-06, Last modification date: 2011-07-13)
Primary citation
Lee, J.K.,Stewart-Jones, G.,Dong, T.,Harlos, K.,Di Gleria, K.,Dorrell, L.,Douek, D.C.,Van Der Merwe, P.A.,Jones, E.Y.,Mcmichael, A.J.
T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement.
J.Exp.Med., 200:1455-, 2004
PubMed: 15583017 (PDB entries with the same primary citation)
DOI: 10.1084/JEM.20041251
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23570.3%2.5%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution