1W72

Crystal structure of HLA-A1:MAGE-A1 in complex with Fab-Hyb3

Summary for 1W72

Related1OGA 1AO7 2CKB 1BD2 1FO0 1MWA 1G6R
DescriptorHLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, MELANOMA-ASSOCIATED ANTIGEN 1, ... (7 entities in total)
Functional Keywordsimmune system, hla/fab fragment, human leucocyte antigen, peptide-specific fab, tcr-like binding, mhc-i
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane; Single-pass type I membrane protein P30443
Secreted P61769
Cytoplasm P43355
Total number of polymer chains10
Total molecular weight182094
Authors
Hulsmeyer, M.,Chames, P.,Hillig, R.C.,Stanfield, R.L.,Held, G.,Coulie, P.G.,Alings, C.,Wille, G.,Saenger, W.,Uchanska-Ziegler, B.,Hoogenboom, H.R.,Ziegler, A. (deposition date: 2004-08-27, release date: 2004-11-09, Last modification date: 2011-07-13)
Primary citation
Hulsmeyer, M.,Chames, P.,Hillig, R.C.,Stanfield, R.L.,Held, G.,Coulie, P.G.,Alings, C.,Wille, G.,Saenger, W.,Uchanska-Ziegler, B.,Hoogenboom, H.R.,Ziegler, A.
A Major Histocompatibility Complex.Peptide- Restricted Antibody and T Cell Receptor Molecules Recognize Their Target by Distinct Binding Modes: Crystal Structure of Human Leukocyte Antigen (Hla)-A1.Mage-A1 in Complex with Fab-Hyb3
J.Biol.Chem., 280:2972-, 2005
PubMed: 15537658 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M411323200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25830.2%1.2%6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 1w72
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1w72.pdb2.gz [138.62 KB])
Coordinate files for Biological unit (1w72.pdb1.gz [139.83 KB])
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