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1AO7

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201

Summary for 1AO7
Entry DOI10.2210/pdb1ao7/pdb
DescriptorHLA-A 0201, BETA-2 MICROGLOBULIN, TAX PEPTIDE, ... (7 entities in total)
Functional Keywordsclass i mhc, t-cell receptor, viral peptide, complex (mhc-viral peptide-receptor, complex (mhc-viral peptide-receptor) complex, complex (mhc/viral peptide/receptor)
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted : P61769
Host nucleus : P14079
Total number of polymer chains5
Total formula weight95026.00
Authors
Garboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C. (deposition date: 1997-07-21, release date: 1997-09-17, Last modification date: 2024-11-20)
Primary citationGarboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C.
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
Nature, 384:134-141, 1996
Cited by
PubMed Abstract: Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
PubMed: 8906788
DOI: 10.1038/384134a0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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