1AO7
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Summary for 1AO7
Entry DOI | 10.2210/pdb1ao7/pdb |
Descriptor | HLA-A 0201, BETA-2 MICROGLOBULIN, TAX PEPTIDE, ... (7 entities in total) |
Functional Keywords | class i mhc, t-cell receptor, viral peptide, complex (mhc-viral peptide-receptor, complex (mhc-viral peptide-receptor) complex, complex (mhc/viral peptide/receptor) |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted : P61769 Host nucleus : P14079 |
Total number of polymer chains | 5 |
Total formula weight | 95026.00 |
Authors | Garboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C. (deposition date: 1997-07-21, release date: 1997-09-17, Last modification date: 2024-11-20) |
Primary citation | Garboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature, 384:134-141, 1996 Cited by PubMed Abstract: Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions. PubMed: 8906788DOI: 10.1038/384134a0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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