1YPZ

Immune receptor

Summary for 1YPZ

• Entry DOI: 10.2210/pdb1ypz/pdb
• Descriptor: H2-T22 protein, Beta-2-microglobulin, T cell receptor delta, ... (7 entities in total)
• Functional Keywords: h2-t22 protein, beta-2-microglobulin, t cell receptor delta, t-cell receptor gamma chain, immune system
• Biological source: Mus musculus (house mouse); More
• Cellular location: Secreted: P61769
• Total number of polymer chains: 8
• Total formula weight: 184680.92

Authors

Adams, E.J.,Garcia, K.C. (deposition date: 2005-01-31, release date: 2005-04-12, Last modification date: 2024-12-25)

Primary citation

Adams, E.J.,Chien, Y.H.,Garcia, K.C.
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Science, 308:227-231, 2005

PubMed Abstract: Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.

PubMed: 15821084
DOI: 10.1126/science.1106885

Experimental method

X-RAY DIFFRACTION (3.4 Å)