1ONQ

Crystal Structure of CD1a in Complex with a Sulfatide

Summary for 1ONQ

• Entry DOI: 10.2210/pdb1onq/pdb
• Related: 1CD1 1GZP 1GZQ
• Descriptor: T-cell surface glycoprotein CD1a, Beta-2-microglobulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: protein-glycolipid complex, beta sheet platform, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 92323.52

Authors

Zajonc, D.M.,Elsliger, M.A.,Teyton, L.,Wilson, I.A. (deposition date: 2003-02-28, release date: 2003-08-05, Last modification date: 2024-11-20)

Primary citation

Zajonc, D.M.,Elsliger, M.A.,Teyton, L.,Wilson, I.A.
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.
Nat.Immunol., 4:808-815, 2003

PubMed Abstract: CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.

PubMed: 12833155
DOI: 10.1038/ni948

Experimental method

X-RAY DIFFRACTION (2.15 Å)