2BNQ

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Summary for 2BNQ

Related1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1CE6 1DE4 1DUY 1DUZ 1E27 1E28 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGE 1JNJ 1JHT 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1K5N 1KPR 1KTL 1LDS 1OF2 1FYT 1KGC 1TMC 2CLR 2HLA 2BNR 3HLA
DescriptorHLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ... (6 entities in total)
Functional Keywordsimmune system/receptor, immune system-receptor-complex, tcr, mhc, immunodominance, flu, complex, transmembrane, glycoprotein, polymorphism, t-cell, receptor, superagonist peptide t-cell vaccines, immune system-receptor complex
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted  P61769
Membrane ; Single-pass membrane protein  2BNQ
Total number of polymer chains5
Total molecular weight94098.48
Authors
Primary citation
Chen, J.-L.,Stewart-Jones, G.,Bossi, G.,Lissin, N.M.,Wooldridge, L.,Choi, E.M.L.,Held, G.,Dunbar, P.R.,Esnouf, R.M.,Sami, M.,Boultier, J.M.,Rizkallah, P.,Renner, C.,Sewell, A.,Van Der Merwe, P.A.,Jackobsen, B.K.,Griffiths, G.,Jones, E.Y.,Cerundolo, V.
Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201:1243-, 2005
PubMed: 15837811 (PDB entries with the same primary citation)
DOI: 10.1084/JEM.20042323
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers130.5%2.4%7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution