2BNQ
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | HOMO SAPIENS (HUMAN) | MHC, A-2 ALPHA CHAIN PRECURSOR |
| 2 | B (B) | BETA-2-MICROGLOBULIN | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | HDCMA22P, B2M |
| 3 | C (C) | SYNTHETIC PEPTIDE | polymer | 9 | 1090.3 | 1 | UniProt (by SIFTS) (P78358) | HOMO SAPIENS | |
| 4 | D (D) | T-CELL RECEPTOR ALPHA CHAIN V REGION | polymer | 203 | 22171.5 | 1 | Pfam (PF07686) Pfam (PF09291) UniProt (by SIFTS) (A0A0B4J279) UniProt (by SIFTS) (P01848) | HOMO SAPIENS (HUMAN) | |
| 5 | E (E) | T-CELL RECEPTOR BETA CHAIN C REGION | polymer | 241 | 27006.0 | 1 | UniProt (P01850) Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (A0A0K0K1A5) | HOMO SAPIENS (HUMAN) | TRBC1 |
| 6 | F, G, H, I, J (A, B, C, D, E) | water | water | 18.0 | 527 | Chemie (HOH) |
Sequence modifications
B: 0 - 0 (PDB: 2BNQ)
B: 1 - 99 (UniProt: P61769)
E: 2 - 112 (PDB: 2BNQ)
E: 113 - 242 (UniProt: P01850)
B: 1 - 99 (UniProt: P61769)
E: 2 - 112 (PDB: 2BNQ)
E: 113 - 242 (UniProt: P01850)
| PDB | External Database | Details |
|---|---|---|
| Lys 116 | Asn 4 | conflict |
| Asn 117 | Lys 5 | conflict |
| Tyr 149 | Phe 37 | conflict |
| Cys 169 | Ser 57 | conflict |
| Ala 187 | Cys 75 | conflict |
| Asp 201 | Asn 89 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94098.5 | |
| All* | Total formula weight | 94098.5 |
