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6NB9	Amyloid-Beta (20-34) with L-isoaspartate 23 Descriptor: Amyloid-beta A4 protein Authors: Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. Deposit date: 2018-12-06 Release date: 2019-08-07 Last modified: 2022-09-07 Method: ELECTRON CRYSTALLOGRAPHY (1.05 Å) Cite: Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
6OIZ	Amyloid-Beta (20-34) wild type Descriptor: Amyloid beta A4 protein Authors: Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. Deposit date: 2019-04-10 Release date: 2019-08-07 Last modified: 2022-09-07 Method: ELECTRON CRYSTALLOGRAPHY (1.1 Å) Cite: Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
5MYX	Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 Descriptor: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18 Authors: Parthier, C, Piechotta, A, Stubbs, M.T. Deposit date: 2017-01-30 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.492 Å) Cite: Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
3IFN	X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein Authors: Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. Deposit date: 2009-07-24 Release date: 2009-11-17 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J.Biol.Chem., 285, 2010
3BAE	Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28) Descriptor: Amyloid Beta Peptide, WO2 IgG2a Fab fragment Heavy Chain, WO2 IgG2a Fab fragment Light Chain Kappa Authors: Miles, L.A, Wun, K.S, Crespi, G.A, Parker, M.W. Deposit date: 2007-11-07 Release date: 2008-04-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.593 Å) Cite: Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J.Mol.Biol., 377, 2008
5MYK	Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb Descriptor: Amyloid beta A4 protein, Fab c#17 heavy chain, Fab c#17 light chain Authors: Parthier, C, Piechotta, A, Stubbs, M.T. Deposit date: 2017-01-26 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
4MVI	Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40) Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin Authors: Eichinger, A, Skerra, A. Deposit date: 2013-09-24 Release date: 2015-08-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016
7U4P	Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins Descriptor: Amyloid-beta 17-36 peptide Authors: Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. Deposit date: 2022-02-28 Release date: 2023-03-15 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.803 Å) Cite: Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. Acs Cent.Sci., 10, 2024
8BG0	Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 Descriptor: Amyloid-beta precursor protein Authors: Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. Deposit date: 2022-10-27 Release date: 2023-01-18 Last modified: 2023-02-22 Method: ELECTRON MICROSCOPY (1.9 Å) Cite: Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
5HOX	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV). Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) Authors: Kreutzer, A.G, Nowick, J.S, Spencer, R.K. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
8KH2	Crystal structure of horse-spleen L-ferritin fused with amyloid beta peptide (1-42). Descriptor: CADMIUM ION, CHLORIDE ION, Ferritin light chain,Amyloid-beta precursor protein (Fragment), ... Authors: Maity, B, Tian, J, Abe, S, Ueno, T. Deposit date: 2023-08-21 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusion of amyloid beta with ferritin yields an isolated oligomeric beta-sheet-rich aggregate inside the ferritin cage. Biomater Sci, 2024
7JXN	Beta hairpin derived from Abeta17-36 with an F20Cha mutation Descriptor: Amyloid-beta 17-36 peptide, CHLORIDE ION, SODIUM ION Authors: Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. Deposit date: 2020-08-27 Release date: 2020-12-09 Last modified: 2020-12-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta. J.Am.Chem.Soc., 142, 2020
3MOQ	Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks Descriptor: New antigen receptor variable domain,P3(40) peptide from Amyloid beta A4 protein,New antigen receptor variable domain Authors: Streltsov, V.A. Deposit date: 2010-04-23 Release date: 2011-02-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.054 Å) Cite: Crystal Structure of the Amyloid-{beta} p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease J.Neurosci., 31, 2011
2G47	Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40) Descriptor: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, amyloid protein beta A4 Authors: Shen, Y, Tang, W.-J. Deposit date: 2006-02-21 Release date: 2006-10-24 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature, 443, 2006
7RTZ	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40 Descriptor: Amyloid-beta protein 40, CHLORIDE ION Authors: Samdin, T.D, Kreutzer, A.G, Nowick, J.S. Deposit date: 2021-08-16 Release date: 2022-08-31 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta Chem Sci, 2023
4ONG	Fab fragment of 3D6 in complex with amyloid beta 1-40 Descriptor: 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... Authors: Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. Deposit date: 2014-01-28 Release date: 2014-06-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab. Alzheimers Res Ther, 6, 2014
4HIX	Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide Descriptor: Beta-amyloid protein 40, Humanized 3D6 Fab heavy chain, Humanized 3D6 Fab light chain Authors: Miles, L.A, Crespi, G.A.N, Parker, M.W. Deposit date: 2012-10-12 Release date: 2013-03-13 Last modified: 2014-03-19 Method: X-RAY DIFFRACTION (2.204 Å) Cite: Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep, 3, 2013
5HOW	X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V Descriptor: Amyloid beta A4 protein Authors: Kreutzer, A.G, Nowick, J.S, Spencer, R.K. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (2.295 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
5HOY	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV). Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) Authors: Kreutzer, A.G, Spencer, R.K, Nowick, J.S. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.295 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
4MVL	Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40 Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin Authors: Eichinger, A, Skerra, A. Deposit date: 2013-09-24 Release date: 2015-08-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016
6WXM	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36 Descriptor: Amyloid-beta protein, HEXANE-1,6-DIOL Authors: Kreutzer, A.G, Nowick, J.S. Deposit date: 2020-05-11 Release date: 2020-07-08 Last modified: 2020-08-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: X-ray Crystallography Reveals Parallel and Antiparallel beta-Sheet Dimers of a beta-Hairpin Derived from A beta16-36that Assemble to Form Different Tetramers. Acs Chem Neurosci, 11, 2020
5BUO	A receptor molecule Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETATE ION, Amyloid beta A4 protein, ... Authors: Gao, C, Crespi, G.A.N, Gorman, M.A, Nero, T.L, Parker, M.W, Miles, L.A. Deposit date: 2015-06-04 Release date: 2016-07-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.31 Å) Cite: NULL To Be Published
5VZY	Crystal structure of crenezumab Fab in complex with Abeta Descriptor: Amyloid beta A4 protein, Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain Authors: Ultsch, M, Wang, W. Deposit date: 2017-05-29 Release date: 2017-08-09 Last modified: 2017-09-13 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin. Sci Rep, 6, 2016
8QN6	Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy Descriptor: Amyloid-beta A4 protein Authors: Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. Deposit date: 2023-09-25 Release date: 2023-12-13 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
4XXD	Crystal Structure of mid-region amyloid beta capture by solanezumab Descriptor: Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain Authors: Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A. Deposit date: 2015-01-30 Release date: 2015-04-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies. Sci Rep, 5, 2015

 

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